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AKAP4 gene is downregulated in sterile hybrid offspring-image

AKAP4 gene is downregulated in sterile hybrid offspring

The cattleyak are the hybrid offspring between cattle and yak and combine yak hardiness with cattle productivity in Tibet and in China. Milk yield is higher in F1 hybrids than in the pure yak and often higher than in the local types of cattle. ...
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The 4MID® Kit To Optimize Semen Cryopreservation-image

The 4MID® Kit To Optimize Semen Cryopreservation

The  4MID® Kits are unique ELISA Kits commercialized by SPQI-4BioDx that allows to objectively select the best semen and therefore will improve cryopreservation success results (by detecting poor freezers).   The  4MID® Kits  are ...
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A Kinase Anchor Protein 4 Is Vulnerable to Oxidative Adduction in Male Germ Cells-image

A Kinase Anchor Protein 4 Is Vulnerable to Oxidative Adduction in Male Germ Cells

Oxidative stress is a leading causative agent in the defective sperm function associated with male infertility. ProAKAP4 is clearly a target of oxidative stress and may be a pertinent read-out to be follow up using the 4MID approach ...
Read more
The International Day of Families!-image

The International Day of Families!

This Thursday, May 15, 2020 was the annual celebration of the International Day of Families! We wish an excellent and joyful day to all "Families", those of blood and those of heart, to all those who gather together, sharing the ...
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LINALUX, OUR PARTNER IN BELGIUM-image

LINALUX, OUR PARTNER IN BELGIUM

The SPQI-4BioDx team is the new partner and collaborator of  Linalux Mont-le-Soie , an European equine center located in Belgium, which has relied on  4MID® Kit  products to improve the reproductive evaluation and breeding of horses at its ...
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Happy Easter!-image

Happy Easter!

Happy Easter! Joyeuse Fête de Pâques ! Peace, Joy and Happiness ! We want to wish all the best on this special time of the year an happy Easter ! Easter gives hope for tomorrow, Easter is a time of reflection and joy. We wish a Pleased, ...
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Biovet, our new distributor in Canada and USA-image

Biovet, our new distributor in Canada and USA

Biovet   is our distributor in Canada and USA which commercialize the 4BioDx products in the area of animal reproduction. You can contact them or us directly to  purchase our products  or to  perform the analysis of your samples  in case ...
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The Bull 4MID® Kit, a new tool  to assess fertility -image

The Bull 4MID® Kit, a new tool to assess fertility

Check out our last results with the  Bull 4MID® Kits to evaluate sperm quality and fertility in Holstein bulls! These results were presented in Gramado (Brazil) during the last CBRA Meeting in May 2019. In this large study, the ...
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Indispensable role of AKAP4 is confirmed in spermatogenesis-image

Indispensable role of AKAP4 is confirmed in spermatogenesis

Akap4-knockout mice line was recently generating using CRISPR-Cas9 system by Fang and collaborators.  The loss of AKAP4 led to abnormal sperm morphology, motility and infertility as previously described by Miki et al. 2008. Their studies ...
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ProAKAP4: A New Parameter to Evaluate the Semen Quality-image

ProAKAP4: A New Parameter to Evaluate the Semen Quality

ProAKAP4 represents today a new molecular parameter to assess the quality of sperm.   Among biomarkers, the specificity of proAKAP4 polypeptide is to be inside the spermatozoa, more precisely in the column and ribbons of the fibrous sheath ...
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Blossom Biotechnologies, our new partner and distributor in Taiwan-image

Blossom Biotechnologies, our new partner and distributor in Taiwan

Thanks to  Blossom Biotechnologies , all 4BioDx products are now available in Taiwan. Our Taiwan customers can now order easily our innovative 4BioDx products via our partner and distributor in Taiwan The  4MID® Kits  are the ...
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The 4MID®  Kit is now available for cat semen-image

The 4MID® Kit is now available for cat semen

An Innovative Test of Sperm Quality called 4MID® Kit is now available for Cat ! The  Cat 4MID® Kit  (Ref. 4VDX-19K10) is the first test that validates objectively semen quality by quantifying a protein biomarker named proAKAP4 in cat semen. ...
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GreenPure : Our Partner in South Korea-image

GreenPure : Our Partner in South Korea

Thanks to  GreenPure , all 4BioDx products are now available in Korea. Our Korean customers can now order easily our innovative 4BioDx products via our partner and distributor in South Korea.  GreenPure  is a well-renowned Korean company ...
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Happy New Year! Bonne Année 2020!-image

Happy New Year! Bonne Année 2020!

Happy New Year from all of us at SPQI - 4BioDx ! And many many thanks to all our partners, customers, distributors, agents and collaborators worldwide that have been there for us! We are so thankful for a great 2019 year and we are sure that ...
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Poster ICAR 2020 (Bologna, Italy)-image

Poster ICAR 2020 (Bologna, Italy)

The  19th ICAR   (International Congress on Animal Reproduction)  will take place from the 28th to the 2th July 2020 in Bologna (Italy). Every 4 years the ICAR meeting gather international experts of animal reproduction. Dr.  Maryse Delehedde , ...
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Joyeux Noël! Merry Christmas!-image

Joyeux Noël! Merry Christmas!

Merry Christmas ! May Joy and Peace be with you all! Partners, customers and collaborators! And more especially to all the members of our team (actual, past and to come :) We really are thankful for this great year 2019 ! ...
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The  4MID® kits now available in Brazil !-image

The 4MID® kits now available in Brazil !

LEAC is now the official distributor of innovative 4BioDx products in Brazil. Located in Sao Paulo,  LEAC is specialized in the sector of analytical laboratories (human and veterinary) as well as in in vitro diagnostic devices. The company ...
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AKAP4 is overexpressed in fertile water buffalo-image

AKAP4 is overexpressed in fertile water buffalo

Fu et al. 2019  have recently identified the marker AKAP4 in the spermatozoa from fertile normozoospermic buffalos, bulls or swines. They also stated that never found in the seminal fluids - Only in cells, spermatozoa. Check out their ...
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Happy Thanksgiving Day-image

Happy Thanksgiving Day

Happy Thanksgiving Day from the 4BioDx teams !  We want to thank all our partners, customers, distributors and friends for this great and wonderful year of success alltogether ! Visit our websites for great offers for this ...
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AKAP4 as a marker of sperm fertility in bulls-image

AKAP4 as a marker of sperm fertility in bulls

AKAP4 transcripts were recently spotted again as the top five validated transcripts significantly increased (p < 0.05) in their level of expression in good quality bull semen compared to the poor quality bulls (classification based on their ...
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ProAKAP4 as a marker of sperm quality in stallions-image

ProAKAP4 as a marker of sperm quality in stallions

Check out our last publication in Theriogenology from our fruitful collaborations with Linalux, Dr. ean-Philippe Lejeune and Pr Didier Serteyn and the University of Liege (Belgium). With applications of the  Horse 4MID kits , the first ...
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AKAP4 as an highly conserved indicator of sperm quality-image

AKAP4 as an highly conserved indicator of sperm quality

In mammals, the spermatozoa must undergo physiological changes, as named as capacitation, in the female reproductive tract prior to be able to fertilize ovocyte. A recent study from Brett Nixon and collaborators in  Mol. Cell Proteomics , ...
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The 4MID® kits are now available in Turkey !-image

The 4MID® kits are now available in Turkey !

Diagen  is now the main distributor of 4BioDx ® products in Turkey. All our innovative may be then purchased from Diagen, including the 4MID ®, the first functional test to assess sperm quality and fertility. To order 4BioDx innovative ...
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proAKAP4 in human spermatozoa-image

proAKAP4 in human spermatozoa

AKAP4 and its precursor called  pro-AKAP4  are two major proteins of the human sheath spermatozoa (Johnson et al., 1997), playing a role in sperm motility and fertility. Spermatozoa without proAKAP4/AKAP4 are abnormal, immobile and infertile ...
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Cosmo Bio Co as a distributor of 4BioDx products in Japan-image

Cosmo Bio Co as a distributor of 4BioDx products in Japan

SPQI - 4BioDx is pleased to announce that  Cosmo Bio Co, Ltd  is now the main distributor of 4BioDx products in Japan ! Cosmo Bio Co, Ltd  is one of the biggest distributor of laboratory reagents in Japan. This well-renowed ...
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BioNovus : The Australian distributor of 4BioDx products!-image

BioNovus : The Australian distributor of 4BioDx products!

SPQI - 4BioDx is pleased to announce that  BioNovus is now the main distributor of 4BioDx products in Australia! To order 4BioDx innovative products, you may then contact directly BioNovus  at  info@bionovuslifesciences.com.au . Or contact ...
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Délivrance d'un brevet aux USA pour SPQI et ses biomarqueurs innovants dans la fertilité masculine-image

Délivrance d'un brevet aux USA pour SPQI et ses biomarqueurs innovants dans la fertilité masculine

Pour la première fois, la société lilloise  SPQI  (Services et Produits de Qualité et Innovants) a obtenu la délivrance d’un brevet par l’United States Patent and Trademark Office (USPTO) le 12 septembre 2017. Ainsi, le brevet délivré par les ...
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The 1st immunoassay to assess semen quality in pig-image

The 1st immunoassay to assess semen quality in pig

Discover our new product: The  Pig 4MID ®   kit The Pig 4MID ®  kit  (Ref. 4VDX-17K2 ) is the first test that validates objectively semen quality by quantifying a protein biomarker named pro AKAP4 in pig semen. The Pig 4MID ® kit ...
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AKAP4 as a biomarker in colon cancers-image

AKAP4 as a biomarker in colon cancers

Kodehi and collaborators (2018) have recently showed that AKAP4 expression is significantly correlated with liver metastasis in colon cancer patients. Therefore AKAP4  may have  a potential as a pronostic biomarker in colon cancer. Cancer ...
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Happy New Year-image

Happy New Year

The SPQI teams thank you for your trust and wish you happiness and success for the year 2019.
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Newsletter subscription / discount voucher-image

Newsletter subscription / discount voucher

Sign up to the newsletter and enjoy 10% off on your next order! After signing up to our newsletter you will receive a voucher by email. To register to our newsletter, just enter your email address in the box "Newsletter" ...
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Li StarFish, distributor of 4BioDx products in Italy-image

Li StarFish, distributor of 4BioDx products in Italy

Thanks to  Li StarFish , 4BioDx products are now available in Italy. Our Italian customers can now order easily our innovative 4BioDx products via our partner and  distributor in Italy .  They may then contact directly Li StarFish at ...
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DPC Lebanon commercializes 4BioDx products in the Middle East-image

DPC Lebanon commercializes 4BioDx products in the Middle East

DCP Lebanon sarl  commercializes 4BioDx innovative products in the Middle East. Now, our customers in Lebanon, in Jordan, in Iran, in Egypt, in KSA, in Qatar, in Bahrain, in Kuwait and UAE can order easily our products! Do not hesitate to contact ...
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Tau hyperphosphorylation and hypothermia in a mice model of Type 2 diabetes-image

Tau hyperphosphorylation and hypothermia in a mice model of Type 2 diabetes

Type 2 diabetes (T2DM) has been linked to a higher risk of Alzheimer's disease. In a recent study, Gratuze et al. (Laval, Canada) have investigated the impact of T2DM on tau phosphorylation in ob/ob mice, a spontaneous genetic model of T2DM ...
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Best autumn offer on all our antibodies-image

Best autumn offer on all our antibodies

Get a 20% Off  when you order online any of monoclonal or polyclonal antibodies ! This is the best time to test by yourself our innovative products. Please discover for instance the Anti-Tau [pS422] antibody, clone 2H9 ( Ref. 4BDX-1501 ...
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Joyeux Noël ! Merry Christmas-image

Joyeux Noël ! Merry Christmas

Joyeux Noël et Belles Fêtes de Fin d'Année à Tous ! Nos équipes seront présentes tous les jours à l'exception du 24 décembre et du 31 décembre 2018. Aucune colis ne partira le 24 et 25 décembre, ainsi que le 31 décembre 2018 et le 1er janvier ...
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New product: The 1st immunoassay to assess spermatozoa quality-image

New product: The 1st immunoassay to assess spermatozoa quality

Discover our new product: The "4MID ®"  ELISA kit The 4MID ® kit  is the first immunoassay (ELISA Kit) that allows you to quantify  human AKAP4 in sperm samples as a biomarker of sperm quality. This product is a research use only ...
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Get a 20% off on all 4BioDx antibodies!-image

Get a 20% off on all 4BioDx antibodies!

To celebrate the arrival of summer, we are glad to offer you a 20 % off on all 4BioDx antibodies references! This is an opportunity for you to test our antibodies in the fields of human reproduction and animal reproduction ...
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SPQI soutient les "Forces Awards 2017"-image

SPQI soutient les "Forces Awards 2017"

La société SPQI soutient les  "Forces Awards 2017"  qui récompensent les réussites issues des travaux de collaboration entre les entreprises et la recherche académique en région Haut-de-France. Cette année la cérémonie aura lieu à Entreprise ...
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ApoE4 Isoforms Differentially Stimulate APP Transcription and A beta Secretion-image

ApoE4 Isoforms Differentially Stimulate APP Transcription and A beta Secretion

Human apolipoprotein E (ApoE) isoforms among which ApoE4, constitute the most important genetic risk factor for Alzheimer's disease (AD) . Up to know, how ApoE isoforms influence Alzheimer pathogenesis remains unclear. Recently, using ...
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"Soutenez la Cigogne"-image

"Soutenez la Cigogne"

Ce projet de  financement participatif  du laboratoire du service de  Biologie de la Reproduction  du Dr Valérie Mitchell a pour but l'acquisition d'un matériel rare et coûteux, un embryoscope, pour donner plus de chances aux couples de ...
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SPQI in the newspaper "La Voix du Nord" / Force Awards -image

SPQI in the newspaper "La Voix du Nord" / Force Awards

Click here   to read the article "SPQI : que les Force (Awards) soient avec la recherche académique" in the newspaper La Voix du Nord (24th of December 2016).  Follow  SPQI - 4BioDx  on  Linked In  ! All our news,  click here
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 SPQI Winner of the 2016 "Force Awards"-image

SPQI Winner of the 2016 "Force Awards"

Maryse Delehedde, President of SPQI was honored to receive two awards at the Force Awards  Ceremony held on the 24th of November 2016 at the Ankama headquarters in Roubaix. On the one hand, SPQI won the trophy in the category ...
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Discover our Mouse / Rat 4MID® Kit

Discover our new Mouse 4MID® Kit, a complete immunoassay that allows you to quantify of the sperm protein called proAKAP4 in mouse or rat semen.   The proAKAP4 marker is a pertinent sperm parameter to be investigated in preclinical, ...
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ProAKAP4: Un Nouveau Paramètre Pour Évaluer la Qualité Du Sperme-image

ProAKAP4: Un Nouveau Paramètre Pour Évaluer la Qualité Du Sperme

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ICAR 2020 (Bologna, Italy)-image

ICAR 2020 (Bologna, Italy)

The  19th annual ICAR   (International Congress on Animal Reproduction)  will take place from the 28th to the 2th July 2020 in Bologna (Italy). Every 4 years the ICAR meeting gather international experts of animal reproduction. Dr.  Maryse ...
Read more

Biovet, our new distributor in Canada and USA

Biovet   is our distributor in Canada and USA which commercialize the 4BioDx products in the area of animal reproduction. You can contact them or us directly to  purchase our products  or to  perform the analysis of your samples  in case ...
Read more

LINALUX, OUR PARTNER IN BELGIUM

The SPQI-4BioDx team is the new partner and collaborator of  Linalux Mont-le-Soie , an European equine center located in Belgium, which has relied on  4MID® Kit  products to improve the reproductive evaluation and breeding of horses at its ...
Read more

The International Day of Families!

This Thursday, May 15, 2020 was the annual celebration of the International Day of Families! We wish an excellent and joyful day to all "Families", those of blood and those of heart, to all those who gather together, sharing the ...
Read more
La Journée Internationale des Familles !-image

La Journée Internationale des Familles !

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A Kinase Anchor Protein 4 Is Vulnerable to Oxidative Adduction in Male Germ Cells-image

A Kinase Anchor Protein 4 Is Vulnerable to Oxidative Adduction in Male Germ Cells

Oxidative stress is a leading causative agent in the defective sperm function associated with male infertility. ProAKAP4 is clearly a target of oxidative stress and may be a pertinent read-out to be follow up using the 4MID approach ...
Read more
The 4MID® Kit To Optimize Semen Cryopreservation-image

The 4MID® Kit To Optimize Semen Cryopreservation

The  4MID® Kits are unique ELISA Kits commercialized by SPQI-4BioDx that allows to objectively select the best semen and therefore will improve cryopreservation success results (by detecting poor freezers). ...
Read more
AKAP4 gene in downregulated in sterile hybrid offstring-image

AKAP4 gene in downregulated in sterile hybrid offstring

Cattleyak are the hybrid offspring between cattle and yak and combine yak hardiness with cattle productivity in Tibet. However male are sterile due to spermatogenic arrest. By testis transcriptome profiling Wu et al. (2020) have identified that ...
Read more