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AKAP4 as an highly conserved indicator of sperm quality

In mammals, the spermatozoa must undergo physiological changes, as named as capacitation, in the female reproductive tract prior to be able to fertilize ovocyte.

A recent study from Brett Nixon and collaborators in Mol. Cell Proteomics, have demonstrated that AKAP4 is marker of capacitation even in crocodiles ! 


The exposure of crocodile spermatozoa to capacitation stimuli induce a cascade of effects that are similar to those observed in mammalian spermatozoa, such as phosphorylation / dephosphorylation in capacitated versus non-capacitated crocodile spermatozoa.

AKAP4 is highly conserved between animals, from reptiles to mammals and appears to a good marker of capacitation in all animals.

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