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Tau hyperphosphorylation and hypothermia in a mice model of Type 2 diabetes

Type 2 diabetes (T2DM) has been linked to a higher risk of Alzheimer's disease. In a recent study, Gratuze et al. (Laval, Canada) have investigated the impact of T2DM on tau phosphorylation in ob/ob mice, a spontaneous genetic model of T2DM (Gratuze et al. 2017). They observed that with aging, ob/ob mice clearly exhibited tau hyperphosphorylation at multiple tau phospho-epitopes. Interestingly they demonstrated that this tau hyperphosphorylation is predominately due to the hypothermia (a consequence to impaired thermoregulation in ob/ob mice) and that a chronic caffeine intake intensified tau hyperphosphorylation by promoting even deeper hypothermia. In conclusion, the authors established a novel link between T2DM and Alzheimer's disease in relation with the predominance of Tau hyperphosphorylation in situation of hypothermia.


More details in Gratuze et al. (2017) Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease. Neurobiol Dis. 98:1-8. (Pubmed)

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